Responsable IRM primates (PhD ICM)

Neuroimagerie animale


Mathieu D. Santin est titulaire d'un doctorat en sciences de l'École Doctorale de Santé Publique Épidémiologie et Sciences de l'Information Biomédicale (2009).


Publications scientifiques


  • J. Foucher, D. Gounot, J. Lamy, M. Santin, A. Vignaud, MM. Roser, P. Loureiro de Sousa, “Multi-parametric quantitative MRI reveals three different white matter subtypes”, submitted in Neuroimage, Jun 2016.
  • C. Horodyckid, M. Canney, A. Vignot, R. Boisgard, A. Drier, G. Huberfeld, C. François, A. Prigent, M. Santin, C. Adam, JC. Willer, C. Lafon, JY. Chapelon, A. Carpentier, "Safe long-term repeated disruption of the blood-brain barrier using an implantable ultrasound device: a multiparametric study in a primate model", Journal of Neurosurgery, Jun 2016.
  • M. D. Santin, M. E. Vandenberghe, A.- S. Herard, L. Pradier, C. Cohen, T. Debeir, T. Delzescaux, T. Rooney, M. Dhenain, “In vivo detection of amyloid plaques by gadolinium-stained MRI can be used to demonstrate the efficacy of an anti-amyloid immunotherapy”, Frontier in aging Neuroscience, Mar 2016.
  • M. D. Santin, M. Didier, R. Valabrègue, L. Yahia Cherif, D. García-Lorenzo, P. Loureiro de Sousa, E. Bardinet, S. Lehéricy, “Reproducibility of R2 * and quantitative susceptibility mapping (QSM) reconstruction methods in the basal ganglia of healthy subjects”, NMR in Biomed, Feb 2016.
  • M. E. Vandenberghe, A. S. Hérard, N. Souedet, E. Sadouni, M. D. Santin, D. Briet, D. Carré, J. Schulz, P. Hantraye, P. E. Chabrier, T. Rooney, T. Debeir, V. Blanchard, L. Pradier, M. Dhenain, T. Delzescaux, “High-throughput 3D whole-brain quantitative histopathology in rodents”, Nature Sci Rep. Feb. 2016.
  • A. Marteyn, N. Sarrazin, J. Yan, C. Bachelin, C. Deboux, M. D Santin, P. Gressens, V. Zujovic, A. Baron-Van Evercooren, “Modulation of the Innate Immune Response by Human Neural Precursors Prevails Over Oligodendrocyte Progenitor Remyelination to Rescue a Severe Model Of Pelizaeus-Merzbacher Disease”, Stem Cells, Dec 2015.
  • O. Cases1, A. Joseph1, A. Obry*, M. Santin*, S. Ben-Yacoub, M. Pâques, S. Amsellem, A. Bribian, M. Simonutti, S. Augustin, J. Alain Sahel, A. Christ, F. de Castro, S. Lehéricy, P. Cosette and R. Kozyraki, “Foxg1-cre mediated Lrp2 inactivation in the developing mouse neural retina, ciliary and retinal pigment epithelia models congenital high myopia”, Plos One, Jun 2015. *Co-second author.
  • P. Kundu*, M. Santin*, PA. Bandettini, ET. Bullmore, A. Petiet, “Differentiating BOLD and non-BOLD signals in fMRI time series from anesthetized rats using multi-echo EPI at 11.7T.”, Neuroimage (102), Nov. 2014. *Co-first authors.
  • M. Santin, R. Valabrègue, I. Rivals, R. Pénager, R. Paquin, L. Dauphinot. C. Albac, B. Delatour, MC. Potier " In vivo 1H Magnetic Resonance Spectroscopy study in microliter voxels in the hippocampus of a mouse model of Down syndrome at 11.7T.", NMR in Biomed, 27(10), Oct. 2014.
  • M. Santin, T. Debeir, S. L. Bridal, T. Rooney, M. Dhenain, "Fast in vivo Imaging f amyloid plaques using µ-MRI Gd-staining combined with ultrasound-induced blood brain barrier opening", Neuroimage (79), Oct. 2013.
  • A. Kraska, M. Santin, O. Dorieux, N. Joseph-Mathurin, E. Bourrin, F. Petit, C. Jan, M. Chaigneau, P. Hantraye, P. Lestage, M. Dhenain, "In Vivo Cross-sectional Characterization of Cerebral Alterations Induced by Intracerebroventricular Administration of Streptozotocin", PLoS One 7(9), Sep. 2012.
  • A. Petiet, M. Santin, A. Bertrand, C. J. Wiggins, F. Petit, D. Houitte, P. Hantraye, J. Benavides, T. Debeir, T. Rooney, M. Dhenain, "Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice", Neurobiology of Aging 33(8), Aug. 2012.
  • N. J. Mathurin, O. Dorieux, A. Kraska, A. Bertrand, M. Santin, N. El Tannir El Tayara & M. Dhenain "Magnetic resonance imaging in primates. The example of the mouse lemur (Microcebus murinus): From detection of pathological aging to therapeutic evaluations", Revue de Primatologie, 2010.
  • R. Diaz-Lopez, N. Tsapis, M. Santin et al., "The performance of PEGylated nanocapsules of perfluorooctyl bromide as an ultrasound contrast agent", Biomaterials 31(7), Mar. 2010.
  • M. Lamuraglia, S.L. Bridal, M. Santin, G. Izzo, A. Paradiso, O. Lucidarme, "Clinical relevance of contrast-enhanced ultrasound in monitoring anti-angiogenic therapy of cancer: current status and perspectives", Critical Reviews in Oncology/Hematology, 73(3), Mar. 2010.
  • M. Santin, D. King, J. Foiret, A. Haak, W. O’Brien Jr., S. L. Bridal, "Encapsulated contrast microbubble radial oscillation associated with postexcitation pressure peaks", Journal of the Acoustical Society of America, 127 (2), Feb. 2010.
  • E. Pisani, N. Tsapis, B. Galaz, M. Santin, R. Berti, N. Taulier, E. Kurtisovski, O. Lucidarme, M. Ourevitch, B. Thuy Doan, J.-C. Beloeil, B. Gillet, W. Urbach, S.L. Bridal and E. Fattal, 2008, "Perfluorooctyl bromide polymeric capsules as dual contrast agents for ultrasonography and magnetic resonance imaging", Adv.Funct.Mater., 18(19), Oct. 2008.



Prochaines conférences

Les cours du CENIR


Retrouvez les cours du CENIR pour les années 2009, 2013, 2014 et 2015 ici




mersin escort